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UNC 1025
CAS No. 1350549-36-8
UNC 1025( —— )
Catalog No. M35372 CAS No. 1350549-36-8
UNC1062 is a highly selective tyrosine kinase inhibitor that specifically targets MERTK.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 129 | Get Quote |
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| 5MG | 164 | Get Quote |
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| 10MG | 259 | Get Quote |
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| 25MG | 415 | Get Quote |
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| 50MG | 585 | Get Quote |
|
| 100MG | 772 | Get Quote |
|
| 500MG | 1539 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameUNC 1025
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NoteResearch use only, not for human use.
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Brief DescriptionUNC1062 is a highly selective tyrosine kinase inhibitor that specifically targets MERTK.
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DescriptionUNC1062 is a MERTK-selective tyrosine kinase inhibitor, reduces activation of MERTK-mediated downstream signaling, induces apoptosis in culture, reduces colony formation in soft agar, and inhibits invasion of melanoma cells. UNC1062 potently inhibits MERTK kinase activity (MERTK IC50=1.1 nM, Morrison Ki=0.33 nM) and exhibits specificity within the TAM family (TYRO3 IC50=60 nM, AXL IC50=85 nM).
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number1350549-36-8
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Formula Weight514.64
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Molecular FormulaC25H34N6O4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 10 mg/mL (19.43 mM; Ultrasonic (<60°C)
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SMILESCCCCNc1ncc2c(nn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Schlegel J, et al. MERTK receptor tyrosine kinase is a therapeutic target in melanoma. J Clin Invest. 2013;123(5):2257-2267. ?
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